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Comparative studies of Caucasian and African populations showed that more mercapturic acid and cysteine conjugate metabolites were recovered in the former (at nearly a 2:1 ratio), indicating that increased hepatic metabolism occurs in that group.43 Another study, which compared Caucasian and Chinese populations indicated the increased susceptibility of the former to APAP hepatotoxicity reflects the lower CYP 2E1 and 2D6 activity in the latter.45 Thus, although no specific limitations on APAP intake have been proposed based on ethnic background, further studies on this topic may yield useful clinical information about the safety profile amongst a diverse patient population

(2015) 54:R3153

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