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doi: 10.1002/jnr.10611 153 ChenSAnFMYinLLiuARYinDKYaoWBet al

To obtain additional restraints for structural model determination of the p53 TAD2 -FOXO4 FH complex, we determined paramagnetic relaxation enhancements (PREs) for a set of 7 complexes containing spin-labeled (SL) samples ( 15 N-labeled FOXO4 FH + S46C-SL p53 TAD2 , 15 N-labeled FOXO4 FH + Q52C-SL p53 TAD2 , 15 N-labeled p53 TAD2 + Q112C-SL FOXO4 FH , 15 N-labeled p53 TAD2 + D140C-SL FOXO4 FH , 15 N-labeled p53 TAD2 + N145C-SL FOXO4 FH , 15 N-labeled p53 TAD2 + S159C-SL FOXO4 FH , 15 N-labeled p53 TAD2 + S162C-SL FOXO4 FH )

A review in 2023 concluded sucrosomial iron (through encapsulation) equals IV efficacy with oral convenience and improved tolerance

DOI: 10.1101/cshperspect.a029694

Preclinical and clinical studies, in fact, demonstrate that glucagon receptor agonism in combination with GLP-1 receptor agonism reduces glucose levels and enables weight loss

Promotes weight loss