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The mechanism involves several pathways: slowing gastric emptying (which helps people feel full longer), reducing appetite signals in the brain, and improving how the body processes glucose

When tirzepatide patients continued into longer-term follow-up, they sustained these losses while semaglutide patients who switched to tirzepatide regained some weight before stabilizing on the new compound

Diabetes 52 , 356364 (2003)

Studies show that digestive slowdown affects roughly one in four people taking GLP-1 therapy, making it one of the most frequently reported side effects