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Additionally, factors such as vesicle size, surface charge, and osmotic pressure contribute to membrane integrity and overall formulation robustness [156]

Other common features include fragile, elastic skin with easy bruising, hypotonia (decreased muscle tone), kyphoscoliosis (kyphosis and scoliosis), and mild osteopenia (loss of bone density)

The impaired gluconeogenesis in PCCA -mutated mice drove higher fatty acid oxidation, which is evidenced by high ketones as shown in Fig

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GLP-1RAs (GLP-1 receptor agonists) are a class of drugs that mimic the action of the GLP-1 hormone and work by stimulating the production of insulin, slowing down food digestion and inducing satiety signals in the body

doi:10.1016/S2213-8587(22)00277-7 9