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Clinical trials used 2.5 mg for a reason

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High copper levels may contribute to oxidative stress, neurological issues, or imbalances

These are earlier in the research pipeline but represent the direction the field is heading

STEP 1 Trial (1,961 adults without diabetes, published in the New England Journal of Medicine, 2021): Participants who received semaglutide 2.4 mg lost an average of 14.9% of their body weight over 68 weeks compared to 2.4% in the placebo group