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however, fewer than 5% of these conditions have approved treatments 3 , underscoring a substantial yet frequently overlooked global health challenge

Dillon et al., in a phase I clinical trial, evaluated a vaccine containing nine breast-cancer-associated peptides (MHC I restricted) from MAGE-A1, 3A3, and AA10 proteins, CEA, NY-ESO-1, and HER2/neu along with a TLR3 agonist, Poly-ICLC, and an adjuvant derived from tetanus toxin

Moreover, we conclude by discussing the molecular advance showing that the endocannabinoid system or related bioactive lipids modulated by the gut microbiota may contribute to the regulation of glucose, lipid and energy homeostasis

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