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This analysis pooled results from trials of participants with mild cognitive impairment (6 trials) and trials of participants without cognitive impairment (15 trials)

The primary theoretical concern is that sustained NAD+ elevation through chronic NNMT inhibition could activate pathways (PARP, SIRT1) that have context-dependent roles in cancer biology NAD+ supports DNA repair and cellular longevity, but also fuels rapidly dividing cells

J.FitzcharlesM

PMC 7815416

MIC B12 injections as monotherapy produce minimal weight loss (1-2 pounds over 12 weeks, not statistically significant)

Some people benefit from weekly injections, while others only need them monthly