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By month 4 to 6, patients with tendon and ligament indications have typically moved from pain reduction and mobility improvement to actual strength restoration in the injured structure

This along with the elevated level of peroxide is a perfect storm for generation of hydroxyl radical, the most reactive and destructive form of ROS

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in the depressed patient, pain is a frequent presenting symptom and a predictor of treatment response (Meyer et al., 2007

Looking ahead, larger, multicenter trials are essential to confirm initial positive outcomes and evaluate long-term safety