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This series included a patient with glucose-6 phosphate dehydrogenase deficiency

Thus, the use of this approach allowed to identify an original target, the protein kinase DYRK1B, suggesting that an inhibitor of this protein could present a possible senolytic activity 40

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Victoza is indicated for diabetes, whilst Saxenda is licensed for weight management under similar criteria to Wegovy Exenatide (Byetta, Bydureon): Available as twice-daily or once-weekly formulations for type 2 diabetes Lixisenatide (Lyxumia): Once-daily injection for type 2 diabetes NICE guidance (NG28) recommends GLP-1 receptor agonists for type 2 diabetes management when certain glycaemic and weight criteria are met

Changhan David Lee, a researcher at USC Leonard Davis School of Gerontology, highlights the importance of mitochondrial biology in research into extending lifespan and healthspan in humans

Another explanation is that large doses of lixisenatide induce desensitization of GLP-1 signals in the brain