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This triggers the UPR, which can promote cell survival or apoptosis depending on the severity and duration of the stress

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41 Because beta-adrenergics do not provide as much antiinflammatory control, their efficacy may be reduced in the presence of inflammation and combination therapy with an antiinflammatory drug (e.g., inhaled or systemic glucocorticoids), or use of theophylline may be indicated

10.1172/JCI122313 91 KishiS.KadoyaH.KashiharaN

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Some conditions may require dose adjustments, stopping Trulicity, or emergency medical care