Ozempic, Wegovy, Mounjaro, and Zepbound may cause digestive side effects
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Additionally, because GLP-1 receptor agonists slow gastric emptying, the absorption of some oral medicines particularly those with a narrow therapeutic index (such as certain anticoagulants or antiepileptics) may be affected
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Clinical trial data and FDA labeling information indicate that gastrointestinal effects are dose-dependent and typically most pronounced during initial treatment or dose escalation
Avoid high-fat meals, cruciferous vegetables (broccoli, cauliflower, cabbage), legumes (beans, lentils), artificial sweeteners (sorbitol, xylitol), and carbonated drinks, as these are harder to digest or produce excess gas when gastric emptying is slowed