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Animal research indicates that exposure to antibiotics early in life, frequently combined with probiotics, perturbs immune development and enhances lifelong risk for metabolic diseases such as obesity and diabetes (199)

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However, the precise kinetics of selenium handover from Prx6 to SEPHS2, the structural determinants that govern selenium selectivity, and the extent to which Prx6 activity becomes rate-limiting during oxidative stress remain unclear

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