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A small increase in heart rate does not automatically mean something is wrong, but it is something your provider may want to monitor

Depending on severity and pattern, it lists dose adjustment, a temporary pause, switching to an oral formulation, or discontinuation as possibilities, and stresses these are decisions for the prescriber

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doi: 10.1016/j.ejmg.2021.104379 4 ButlerMGManzardoAMHeinemannJLokerCLokerJ

Manders Overlap Coefficient analysis to evaluate the goodness of model to map fit was done using TEMPy2 (ref