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Korean J Inter Med

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We previously established a procedure to induce human embryonic stem cells (hESCs) to differentiate into cardiomyocytes ( 2 Materials and methods 2.1 Cardiomyocyte generation and treatment Cardiomyocytes were differentiated from hESCs (H1 cell line)

Interestingly, the insulin/IGF-1 pathway displays an antagonistic pleiotropy with aging, i.e., during development insulin/IGF-1 signaling has fundamental functions in cellular differentiation and the growth of animals, whereas later in the life, it regulates metabolism but its activity clearly accelerates the aging process [1, 2]