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KPV has the strongest preclinical case for gut inflammation
It lightens skin and clears blemishes
Notably, the STEP (Semaglutide Treatment Effect in People with obesity) trials, which specifically examined body composition, demonstrated substantial weight loss compared with placebo (NCT03548935) [53], and reductions in fat mass and visceral adipose tissue were accompanied by decreases in lean mass, although the proportion of lean mass relative to total body mass increased (NCT04074161) [54]
With recent FDA enforcement against misleading direct-to-consumer prescription drug advertising, telehealth and DTC platforms that advertise GLP-1 products will likely need more careful legal / regulatory oversight of their ad claims, especially around benefit claims and safety disclosures
This pattern has been consistent across multiple studies and patient populations, indicating that weight loss achieved through GLP-1 therapy depends on the medication remaining active in your system
Glutathione for skin lightening: a regnant myth or evidence-based verity?, PMC
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