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Furthermore, challenges such as low drug concentration at the local pathological site after systemic administration, limited target specificity and short drug half-life persist [6]

This class of drugs also may promote weight loss by reducing appetite and delay gastric emptying, thereby leading to reduced food intake

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Variants such as GLP1R rs6923761 and FTO rs9939609 relate to GLP-1 receptor sensitivity and metabolic regulationfactors that may have additional relevance for post-thyroidectomy patients whose baseline metabolism is already altered

When gut microbiome composition shifts, it can reduce the protective bacterial populations that serve as the first line of defense against urinary pathogens

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