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Proceedings of the National Academy of Sciences, USA 118, 51

it showed that risk rises with long-term high Lp(a).[ref] Waist-to-hip ratio as a modifying factor for atherosclerosis: A 2025 study involving ~800 people with Lp(a) over 50 mg/dL showed that those with a larger waist-to-hip ratio (more belly fat) were at a much higher risk of atherosclerosis

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Plutzkys team did emphasize that this study was built to study high-risk heart patientsthey were not evaluating the drugs impact when it comes to reducing the risk of first-time cardiovascular events in patients with no previous heart issues.