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Challenges and Limitations Methodological Issues in Vitamin D Research The vitamin D research literature is complicated by several methodological challenges that affect interpretation and clinical application

Distribution The volume of distribution at steady state (Vss) for both free and total cobalamins-(III) showed no apparent relationship to dose

While the vast majority of people absorb enough B12 through their regular, balanced diet, there are some patients for whom this is much more difficult

Oral medications, including antibiotics or hormonal therapies, might also be prescribed depending on the underlying cause

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Furthermore, some commenters stated that the MA non-interference clause at section 1854(a)(6)(B)(iii) of the Act bars CMS from requiring particular price structures in MA provider contracts and therefore prohibits CMS from ever ensuring any correlation between MA rates and resource use