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These pathways are involved in appetite, fullness, digestion, and blood-sugar regulation

Older adults may have higher risk factors for B12 deficiency due to gastrointestinal disorders, dietary factors, or certain medications (like proton pump inhibitors or metformin) that can interfere with B12 absorption

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This may create slightly higher initial sleep disruption potential, but also produces the most dramatic weight loss and therefore the largest eventual sleep apnea improvements

Obesity deserves special attention since it links to a 30% higher risk of differentiated thyroid cancer [3]

Side effects vary by hormone and delivery method