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Among them, OPG (decoy receptor for RANKL) blocked the interaction between RANKL (NF-B ligand) and RANK, miR-21-5p downregulated Acvr2a, and let-7b-5p significantly downregulated the expression of osteoclast-related genes, which ultimately inhibited the germination and differentiation of osteoclasts

A recent study provided a new perspective on mitochondrial glutamine metabolism, offering mechanistic insights into metabolic adaptation during tumor hypoxia, the emergence of drug resistance, and glutaminolysis-induced metabolic reprogramming and presenting metabolic strategies to target glutamine metabolism in cancer cells

[18] The GPX4's appear to play a greater role in the fish GPX system than in mammals