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As a recent scientific review explains, 4 Owing to its size and charged nature, NAD+ cannot passively pass through cellular membranes, including the plasma membrane. ...this probably occurs indirectly through the generation of NAD+ degradation products, such as NMN, NR or NAM, which act as precursors. In other words, NAD+ taken orally must first be broken down into these smaller molecules before it can re-enter cells and contribute to NAD+ synthesis

Pettigrew NE, Brush EJ, Colman RF (2001) 3-Methyleneoxindole: an affinity label of glutathione S-transferase pi which targets tryptophan 38

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Collagen is the body's most abundant protein, making up to 30% of total body protein

In: Lanza R, Langer R, Vacanti J, editors

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