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Liu C et al., 2018

Only Tesamorelin has FDA/EMA approval, with extensive clinical trial data supporting its use in HIV-associated lipodystrophy

In rat, mouse and rabbit models without systemic inflammation, the other GLP1-receptor agonists (except exendin-4), dose dependently caused reduced fetal weight and/or growth, retardation of ossification, irregular ossification, and/or skeletal variants such as wavy ribs ( Table 1 )

However, this is controversial and not fully conclusive

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