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That means the gallbladder empties less frequently and more slowly. At the same time, rapid weight loss can change the composition of bile

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However, an HbA1c threshold of 8.0% (64 mmol/mol) was considered more clinically realistic, as patients are often not treatment-intensified in a timely manner in the UK [46]

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Published Phase 3 weight-loss results for retatrutide exceed those for tirzepatide (22.5% in SURMOUNT-1) and semaglutide (14.9% in STEP-1) at comparable timepoints