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(PubMed) Rayman MP, Infante HG, Sargent M

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Bioavailability comparisons illustrate the advantage clearly

If you have people eat the same meal, but chew each bite either 15 times or 40 times, the blood levels of the appetite-suppressing hormone GLP-1 in the blood stream are higher after 40 chews than 15

Tirzepatides drug label explicitly warns patients on the pill to switch to non-oral contraception or use backup forms of birth control, but theres still a lot we dont know about how these drugs interact with contraception