Carrier-mediated transport ensures high tissue-to-plasma concentration ratios in tissues that depend critically on fatty acid oxidation, such as heart and muscle
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Conflict of interest The authors declare the following conflicts of interest: MS-R has received honoraria for presentations from HRA Pharma
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Nowadays, FOXO4-DRI studies are focused on the following aspects: osteoarthritis (senescent chondrocyte clearance), metabolic dysfunction (insulin resistance and obesity-associated senescence), neurodegeneration (eliminating senescent brain cells), and fibrotic diseases (idiopathic pulmonary and liver fibrosis)
In acute inflammation, cytokine production is typically a short-term response aimed at combating infection and facilitating healing (154)
