Their oral bacterial ecology already favors cavity-producing organisms, and reduced saliva removes one of the few remaining protective barriers
The weekly injection of erythromycin treatment helped overweight patients lose 22% of their weight within 36 weeks
Jos Morales, MD, a vascular neurologist and neurointerventional surgeon at Providence Saint Johns Health Center in Santa Monica, CA, also not involved in this review, told MNT that microglias effect on the neurovascular unit has been associated with dementia. He suggested that: [GLP-1 drugs] could potentially modulate inflammation to reduce the propensity for developing dementias such as Alzheimers disease, particularly in the setting of metabolic syndrome. Morales also explained that in people who have glycemia or type 2 diabetes, the inflammation of the blood-brain barrier can lead to progressive damage to the brain over longer periods. He noted that trials that combine neuroimaging techniques that measure the blood-brain barrier and GLP-1 treatment are needed and could prove that these drugs have neuroprotective benefits.
Here is the chain of events
The FDA issued a warning to consumers about using compounded versions of GLP-1 medications
The Wikipedia overview of Retatrutide provides additional trial context
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