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Inhibition of Gln metabolism significantly reduces cFLIP levels, leading to the formation of the death-inducing signaling complex mediated by TRAIL
The first and rate-limiting step is catalyzed by the enzyme glutamate-cysteine ligase (GCL), which fuses glutamate and cysteine
1 H NMR (400 MHz, DMSO-d6) = 4.78 (s, 2H), 3.52 (t, J = 7.0 Hz, 4H), 2.66 (t, J = 7.1 Hz, 4H), 1.53 (s, 6H)
11 Humans risk overexposure from environmental concentrations that occur naturally (eg, arsenic-rich mineral deposits) or human activities (eg, lead or mercury release as a result of industrial pollution)
One panel member abstained from voting