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Structural design Design delivery systems with specific structures and morphologies, such as multilayer nanoparticles or core-shell structured microspheres, to achieve pulsed or targeted drug release

By contrast, peptide GLP-1RA COM patents are built on a different logic: claims that cover the precise peptide sequence and its specific modifications, with limited genus scope because the SAR around peptide modifications is exquisitely position-specific

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Mascherbauer J, Marzluf BA, Tufaro C et al (2013) Cardiac Magnetic Resonance Postcontrast T1 Time Is Associated With Outcome in Patients With Heart Failure and Preserved Ejection Fraction

KEY POINTS The GPX1 gene codes for the GPx-1 enzyme