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In addition to LC3, several groups have developed some specific macrophage substrates to monitor autophagic flux, such as p62/SQSTM1 (151, 152), BRCA1 gene 1 protein (NBR1) (151), betaine-homocysteine s-methyltransferase (153), and polyglutamine protein aggregates (154)

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Additional testing if symptomatic: Iron studies if fatigued, magnesium if experiencing cramps, and amylase/lipase if experiencing persistent abdominal pain (to rule out pancreatitis, a rare but serious side effect)

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System X c is a transmembrane transporter of cystine and glutamic acid, composed of solute carrier family 7 member 11 (SLC7A11) and solute carrier family 3 member 2 (SLC3A2) [23]