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Because the mouth has a rich blood and lymphatic supply, oral melanoma tends to spread early, about a third of patients have lymph node involvement at the time of diagnosis, and about a quarter have distant metastasis (spread of cancer cells to other parts of the body)

Finally, for each set, we tested whether the proteins in the set were highly ranked in terms of treatment effect relative to proteins not in the set

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Acknowledging that significant weight loss involves psychological adjustment helps set realistic expectations