The clinical trials supporting GLP-1 medications didn't include antioxidant supplementation, and post-market real-world data hasn't identified oxidative stress as a limiting factor in treatment outcomes
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One study found that people with non-alcoholic fatty liver disease whose liver health got better after they got high doses of GSH through an IV for four months
Oral GLP-1 medications like oral semaglutide (Rybelsus) are daily medications with different pharmacokinetics than weekly injectables
doi: 10.1371/journal.pone.0047891 132 ArizaMERivaillerPGlaserRChenMWilliamsMV
Board-certified dermatologist and AAD member, Marisa Garshick, MD, FAAD, tells Personal Care Insights that the injectable pathway distinguishes the safety considerations from topicals, particularly when peptides are used for cosmetic indications