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Exendin-4 is a high potency agonist and truncated exendin-(939)-amide an antagonist at the glucagon-like peptide 1-(736)-amide receptor of insulin-secreting beta-cells

It is an inherent consequence of how the medication works

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The pen versions of GLP-1s are delivered via subcutaneous injections meaning they are injected into the fatty tissue layer just below the skin, typically in the abdomen, thigh, or upper arm