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If your symptoms are not improving, are getting worse, or feel severe in any way, contact your healthcare provider right away rather than waiting it out.

Some of these drugs are now also approved to reduce the risk of heart attacks , strokes, and heart-related deaths in certain populations

Most treatment discontinuations were due to gastrointestinal AE and occurred during the rapid escalation phase this may be mitigated with more gradual dose escalation at phase 3 trials

Winzeler B et al

Other options are also in development