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Both longitudinal melanonychia and subungual bleeding have a range of benign and malignant causes (see Table 4)

High-dose use While trials have tested up to 1200mg/day (even as high as 2400mg/day) and illustrated safety, some report higher rates of gastrointestinal side effects, dizziness, and skin reactions at these levels.14 28 38 Additionally, these higher doses are often short-term (35 weeks) and used under clinical supervision

[Google Scholar] Hatab H

doi: 10.1016/j.biopha.2019.109131 144 ZhangX.ZhaoY.XuJ.XueZ.ZhangM.PangX.et al

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