glutathione synthetase inhibitor Frontiers Glutathione synthesis and recycling. Glutathione

Mol Cell 59, 298308, 10.1016/j.molcel.2015.06.011 (2015)

That turns a molecule designed for pulsatile behavior (in and out over a few hours) into something circulating at potentially 1,000 times normal elevation for nearly a week

The unbound B12 then combines with another protein (called intrinsic factor, which is secreted by cells in the stomach) before it is absorbed by the body in the small intestine and put to work

Gesta, S., Tseng, Y

This suggests its potential in treatment

Inhibition activities were measured as described ( Inhibition of Microsomal Prostaglandin E 2 Synthase 1 (mPGES-1) in a Cell-Free Assay The enzyme activity of human recombinant microsomal prostaglandin E 2 synthase 1 (mPGES-1) was measured by assessment of PGH 2 conversion to PGE 2 ( 2 was added to start the reaction