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62 Lixisenatide Lixisenatide was developed by Sanofi to treat T2DM

The biology of incretin hormones

GIP signaling may add metabolic effects

GLP-1R triggers various intracellular signaling pathways, such as the cAMP/PKA and PI3K/Akt pathways, by binding to endogenous GLP-1 or exogenous agonists, resulting in the enhancement of insulin secretion, inhibition of glucagon secretion, as well as anti-inflammatory and antioxidant stress response

Furthermore, long-term fracture risk, bone microarchitecture changes, and implant survival in GLP-1 agonist users remain poorly studied

Environmental factors like air, light, and pro-oxidant excipients exacerbate this process