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Pens deliver very consistent exposure with simple training

Common side effects Nausea (the most common one across both) Constipation Diarrhoea Fatigue (in early weeks) Vomiting (Commonly during dose increases) Most are gastrointestinal, mild to moderate, and improve significantly after the dose escalation phase

Mechanism of Action GLP-1 Receptor Agonist: Semaglutide mimics the action of the glucagon-like peptide-1 (GLP-1) hormone, which plays a role in glucose metabolism and appetite regulation

The drug's ability to mimic the effects of GLP-1, a hormone that regulates blood sugar and appetite, contributes to its efficacy

This tripeptide was first identified in human plasma in the 1970s

Summary Microdosing is typically treated as a tolerability-first, clinician-guided approach, involving starts below the usual 2.5 mg step, extending escalation windows from 4 to 8 weeks or more, or pausing at intermediate maintenance doses, such as 5 mg or 7.5 mg, to prioritize steady adherence and symptom control