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Exp Cell Res 347:322331

Caturano A, et al

Muscle Loss and Metabolic Complications When calorie intake falls significantly below maintenance needs, the body preferentially burns muscle tissue for energy because muscle requires more calories to maintain than fat

As demonstrated by MP0250 28 , the therapeutic protein's half-lives can be significantly extended by genetically fusing non-HSA-binding DARPins or other therapeutic proteins to albumin-binding DARPins

Lowering body weight in obese mice with diastolic heart failure improves cardiac insulin sensitivity and function: implications for the obesity paradox