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GLP-1 is thought to mediate this through inhibiting Rho GTPase in the cyclic adenosine 3,5-monophosphate (cAMP)/protein kinase A (PKA) pathway [25]

Some cases allege that the drugs cause or exacerbate gallstones and gallbladder disease, in some cases requiring surgical removal of the gallbladder

Wang X, Hu A, Chen X, Zhang Y, Yu F, Yue S, et al

Blood tests may be required to exclude hypothyroidism, anaemia, iron deficiency, or vitamin B12 deficiency as underlying causes

Ascierto ML, Melero I, Ascierto PA

However, in the presence of hypoxia and excess hemin exposure along with supraphysiological concentrations of cystine, we readily detected the ability of DMF in contributing cysteine availability (Fig