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If after several minutes it's still not dissolving, ensure your solvent choice is correct and your technique is gentle

OTUs were assigned using a closed-reference OTU picking approach, which referenced picks against SILVA (NR132) database [35, 36] by using UCLUST algorithm [37] with 97% of sequence identity

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C677T methylenetetrahydrofolate reductase gene polymorphisms in bipolar disorder: an association study in the Chinese population and a meta-analysis of genetic association studies