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The main published Phase 2 obesity study looked at retatrutide in adults with obesity, or overweight with at least one weight-related condition

The conventional concern that glucagon raises blood glucose and would offset the glucose-lowering goal of GLP-1/GIP agonism is addressed in the published mechanism literature by examining the tissue-specific and timing-specific actions of each receptor arm

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Moreover, the magnitude of WL with retatrutide also exceeded that seen with other pipeline multi-agonists such as CagriSema (cagrilintide, an amylin agonist, in combination with semaglutide), mazdutide and survodutide (Fig