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Last medically reviewed: 2026-06-08 by GLP3 Planner editorial

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The New England journal of medicine, 384(11), 9891002

For Hashimoto's patients, it is particularly concerning because muscle mass directly influences basal metabolic rate, which is already compromised by thyroid dysfunction

This multi-target design represents a significant advance beyond both the single-agonist GLP-1 receptor agonists (such as semaglutide) and the dual GIP/GLP-1 agonists (such as tirzepatide)