Regarding average changes in HbA1c levels, tirzepatide demonstrated both non-inferiority and superiority to semaglutide at all doses [80, 81]
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The intent of this change is to drive improved health outcomes, which could have substantial benefits and downstream impacts, but if enacted, the proposed changes will expand coverage criteria, significantly impacting health plans in quick time
If DEXA scans are not accessible, waist circumference and body measurements provide useful proxies