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Indeed, HGF increases the proliferation of cerebellum granule cell precursors and this effect is reduced in a hypomorphic MET mutant (Grb2-binding incompetent) that leads to a smaller size of the cerebellum (Ieraci et al., 2002)

The rationale for combining NAD+ precursors with tirzepatide is similar to that for niacinamide, but with potentially greater potency due to higher NAD+ bioavailability

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