It does not mean a compound is unsafe
One study showed that 54% of the HINNAO Glutathione was delivered into the bloodstream within 40 seconds, 80% within 60 seconds and 83% within 90 seconds.2 Another randomised, double-blind, placebo-controlled, parallel, three-arm study conducted with 60 volunteers showed glutathione effectively influenced skin properties such as reducing skin pigmentation and improving elasticity.3 The healthy female subjects were equally randomised into three groups and took GSH (250 mg/d), GSSG (250 mg/d), or placebo orally for 12 weeks
GSH is connected to the hepatotoxicity of acetaminophen because it is used by the liver to bind a toxic byproduct (NAPQI) of acetaminophen metabolism
ShuQKangCLiJHouZXiongMWangXet al
Attenuation of lipopolysaccharide-induced acute lung injury by hispolon in mice, through regulating the tlr4/pi3k/akt/mtor and keap1/nrf2/Ho-1 pathways, and suppressing oxidative stress-mediated Er stress-induced apoptosis and autophagy
Summary of key findings: In vitro: reduced oxidative stress, improved cell function