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High levels of CaO in soft tissues may result in unregulated production of reactive oxygen species (ROS), provoking an inflammatory response and subsequently damaging the tissue 125

In addition to modulation of energy metabolism and mitochondrial function in CRC, we demonstrate for the first time, that metformin significantly radiosensitises both radiosensitive HCT116 colon cancer and radioresistant SW837 rectal cancer cells to a clinically-relevant dose of 1.8 Gy X-ray radiation

doi:10.1002/mnfr.201900797 221