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No large-scale human trials have evaluated combination protocols, so effects remain investigational

First, it is able to bind directly to substrate-binding sites of isozymes to inhibit GST

However, it remains unclear which proteins function as readers in this process and how they contribute to downstream regulation

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The standard group received metformin monotherapy [500 mg three times daily (TID)] for 12 weeks, whereas the semaglutide-intensified treatment group received metformin and semaglutide for 12 weeks