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Hence, subsequent trials administered GDNF through either parenchymal infusions into the striatum 48 or via gene therapy to transfect the host, but with overall negative results 10,40,50

Major depression 95 and Somatic, Anhedonia and Depressed domains were probed with the Center for Epidemiology Depression questionnaire 96,97

Bspbio_002394 89

The cardiovascular, gastrointestinal, and central nervous system effects should be carefully considered before initiating tesofensine therapy

Study 5: Trammell 2016, pharmacokinetics Citation: Trammell S.A., Schmidt M.S., Weidemann B.J., et al

Both substantially outperform currently available medications