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The STEP (Semaglutide Treatment Effect in People with obesity) trials showed that participants lost approximately 1520% of their body weight over 68 weeks, with body composition analyses indicating that roughly 2040% of the total weight lost was lean mass

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[DOI] [PMC free article] [PubMed] [Google Scholar] 248.Hussain T., Tan B., Yin Y., Blachier F., Tossou M.C., Rahu N