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Finally, we showed that pharmacological inhibition of the thioredoxin system by the chemotherapeutic drug arsenic trioxide (ATO) enhanced MTX cytotoxicity in vivo against one out of four primary human ALL cells, suggesting a novel therapeutic rationale to be further explored against ALL

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They all operate within the growth hormone (GH) axis and are staples in research for that very reason

In addition to its role in stress regulation, tryptophan modulates immune responses by influencing the balance between the serotonin and kynurenine pathways